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Because Phil Winslow has a new chance for his work, he decides to move to new neighborhood with his wife, three kids and their beloved Great Dane, Marmaduke. In new place, he must deal with problems which is created by his oversized dog.
This is another opus to take that small, well-trodden step from the funny pages to the big screen. But we're in live-action territory here, meaning that real people actors compete for camera time with real dog actors.